Industries and lung cancer: A population-based case-control study in British Columbia |
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| Authors: | N. Yenugadhati N.J. Birkett F. Momoli D. Krewski |
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| Affiliation: | 1. R.Samuel McLaughlin Centre for Population Health Risk Assessment, University of Ottawa , Ottawa, Ontario, Canada , K1N 6N5;2. Department of Epidemiology and Community Medicine , University of Ottawa , Ottawa, Ontarionyenugad@uottawa.ca;4. Department of Epidemiology and Community Medicine , University of Ottawa , Ottawa, Ontario |
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| Abstract: | An investigation was conducted to identify high-risk industries for histological subtypes of lung cancer based on a large population-based case-control study in British Columbia, Canada. Occupational histories and information on smoking and relevant covariates were collected from 14,755 male incident cancer cases. Industrial risk factors for 2998 lung cancer cases, including histological subtypes were assessed by logistic regression using other cancer cases, excluding smoking-related cancers, as controls. An excess risk of lung cancer was found among workers in mining, metal manufacturing, and electric power systems for all histological-subtypes, and construction, water transport, health services for specific histological subtypes. Industrial associations that are unique to histological subtypes of lung cancer were identified. Future research needs to focus on confirming these histological associations, and identifying the risk from key exposures found within these industries (e.g. medical radiation, electromagnetic fields, and cooking fumes). |
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| Keywords: | industries lung cancer case-control study histological subtypes logistic regression |
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