Synthesis and evaluation of antioxidant activities of some indole-2,3-dione derivatives and analogs |
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Authors: | Chinnasamy Rajaram Prakash Theivendran Panneerselvam Sundararajan Raja |
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Affiliation: | 1. DCRM Pharmacy College , Pharmaceutical Chemistry , Inkollu 523167, Andhra Pradesh, India crp2020@gmail.com;3. DCRM Pharmacy College , Pharmaceutical Chemistry , Inkollu 523167, Andhra Pradesh, India;4. Bharat Institute of Technology , Pharmaceutical Chemistry , Hyderabad, India |
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Abstract: | In the present study, a series of novel Schiff bases of isatin were synthesized by condensation of imesatin with different aromatic aldehydes. The imesatins were synthesized by reaction of isatin with p-phenylenediamine. The chemical structures of the synthesized compounds were confirmed by means of IR, 1H-NMR, 13C-NMR, mass spectroscopy, and elemental analysis. These compounds were screened for antioxidant activity by DPPH, nitric oxide and hydrogen peroxide radical scavenging activity. In all the methods, the compound 3-(4-(3,4,5-trimethoxy benzylideneamino)phenylimino) indoline-2-one (5d) showed highest antioxidant activity because of the presence of electron donating groups and the compound 3-(4-(4-nitrobenzylideneamino)phenylimino) indoline-2-one (5f) showed the least activity because of the presence of an electron withdrawing group. |
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Keywords: | isatin Schiff base antioxidant |
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