Deltamethrin-induced alteration of iron metabolism in Wistar rats |
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Authors: | Afshan Syed Abbas Kiran Shahzad Nadeem Sheikh Mehwish Tanveer |
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Institution: | 1. Department of Zoology, Lahore College for Women University, Lahore, Pakistan;2. Department of Zoology, University of the Punjab, Lahore, Pakistan |
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Abstract: | AbstractThe impact of sub-lethal exposure to deltamethrin on the expression of hepcidin, ferroportin and transferrin genes in Wistar rats was studied. A dosage of 30?mg/kg per day for five days was found to modify the hepcidin-ferroportin axis that primarily governs iron homeostasis. Significant variations in erythrocyte, leukocyte, lymphocyte, platelet and monocyte counts, as well as the reduced serum protein profile, suggested anemia. The results collectively demonstrated the novel finding of deltamethrin’s disruptive effect on iron homeostasis. |
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Keywords: | Pesticides deltamethrin pyrethroid iron hepcidin ferroportin transferrin |
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