Metabolites of sulfur‐containing derivatives of the fungicides pentachloronitrobenzene and hexachlorobenzene in mammals,separated by capillary gas chromatography and identified by negative and positive Cl mass spectrometry |
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| Authors: | L Mayring H Prigge G Renner |
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| Institution: | 1. Institut für Pharmazie und Lebensmittelchemie der , Ludwig‐Maximilians‐Universit?t München , Sophienstra?e 10, München 2, D‐8000, Federal Republic of Germany;2. Consortium für elektrochemische Industrie GmbH , Zielstattstra?e 20, München 70, D‐8000, Federal Republic of Germany;3. Walther‐Straub‐ Institut für Pharmakologie und Toxikologie der , Ludwig‐Maximilians‐Universit?t München , Nussbaumstra?e 26, München 2, D‐8000, Federal Republic of Germany |
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| Abstract: | Biotransformation products of sulfur‐containing derivatives of pentachloronitro‐benzene and hexachlorobenzene in mammals, such as thiophenols, thioanisoles, phenols, anisoles and chlorinated benzenes have been identified by mass spectrometry of negative and positive ions produced by chemical ionisation. The capillary gas chromatograms of extracts from excreta of rats after application of N‐acetyl‐S‐(pentachlorophenyI)‐D,L‐cysteine, as well as of rabbits after application of S,S'‐(tetrachloro‐p‐phenylene)‐L,L'‐dicysteine, are shown. |
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| Keywords: | Fungicide metabolism thiophenol cysteine derivative |
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