Nickel toxicity in partially hepatectomized rats: I. accumulation of radioactive nickel in various organs and subcellular fractions of liver |
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| Authors: | P P Dwivedi V S Misra |
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| Institution: | 1. Industrial Toxicology Research Centre , P.O. Box 80, Mahatma Gandhi Marg, Lucknow, India;2. Chemistry Department , Lucknow University , Lucknow, India |
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| Abstract: | The distribution of radioactive nickel (50 μmol/kg/200μ Ci S.C.) was studied in various organs as well as in the hepatic subcellular fractions of sham operated and partially hepatectomized rats at 16 hr after injection. 63Ni was maximally accumulated in kidney followed by lung, liver, heart and spleen. The incorporation of 63Ni was lowered in partially hepatectomized rats compared to sham operated ones. Subcellular binding of 63Ni showed significantly high affinity of nickel to cytosol followed by nuclear, mitochondria and microsomes in both the groups. |
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| Keywords: | Partial hepatectomy sham operation nickel toxicity subcellular fractions incorporation |
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