Induction of gene mutations in salmonella and Drosophila by soluble Cr(Vi) compounds: Synergistic effects of nitrilotriacetic acid |
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| Authors: | C Gava R Costa M Zordan P Venier V Bianchi A G Levis |
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| Institution: | Department of Biology , University of Padua , Padua, 35131, Italy |
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| Abstract: | The interaction between NTA and soluble Cr(VI) (K2Cr2O7) was studied by the Ames test on S. typhimurium and the sex‐linked recessive lethal test on D. melanogaster. In both systems a synergistic effect of NTA on Cr(VI) mutagenicity took place at sub‐toxic doses of Cr(VI). The synergism could depend on the action of NTA on intracellular Cr(VI) reduction, as more Cr(VI) was reduced in vitro to Cr(III) by Salmonella and Drosophila protein extracts in the presence of NTA. A similar enhancement of soluble Cr(VI) mutagenicity was produced by low doses of EDTA. |
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| Keywords: | Salmonella Drosophila Ames test sex‐linked recessive lethals NTA soluble Cr(VI) synergism repair mutagenicity reduction to Cr(III) chelation spectrophotometry |
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