Sub-chronic exposure to carbendazim induces biochemical and hematological alterations in male goats |
| |
Authors: | Prashantkumar Waghe S. P.S Saini S. Rampal N. Prakash L. V Lokesh |
| |
Affiliation: | 1. Department of Veterinary Pharmacology and Toxicology , Veterinary College , Shivamogga , Karnataka , 577 204 , (India);2. Department of Veterinary Pharmacology and Toxicology College of Veterinary Sciences , GADVASU , Ludhiana , Punjab , 141 004 , (India) |
| |
Abstract: | The present investigation reports the effect of repeated (90 days) administration of carbendazim on the biochemical and hematological parameters in male goats. Carbendazim administered orally at a daily dose of 50 mg kg?1 body weight for 90 consecutive days resulted in increased plasma concentration of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), gamma-glutamyl transferase (GGT), creatinine and albumin, while alkaline phosphatase (ALP) and glucose levels were decreased. Decrease in total leukocyte (TLC) and neutrophil count and increase in lymphocyte count was observed in the treatment group. The findings of the present investigation indicate that sub-chronic exposure to carbendazim in male goats causes hepatic and slight kidney dysfunctions. |
| |
Keywords: | carbendazim toxicity male goats enzymatic changes liver kidney |
|
|