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Transthyretin (prealbumin) binding of PCBS, a model for the mechanism of interference with vitamin A and thyroid hormone metabolism |
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| Authors: | A. Brouwer K.J. van den Berg W.S. Blaner Dew.S. Goodman |
| Affiliation: | Radiobiological Institute TNO, 151 Lange Kleiweg, 2280 HV, Rijswijk, The Netherlands Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, U.S.A. |
| Abstract: | In this study a direct interaction of a metabolite of 3,4,3′,4′-tetrachlorobiphenyl with transthyretin (prealbumin) was observed, leading to reduced plasma levels of retinol, RBP and thyroxin in rats and mice. |
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