Immunotoxic effect of arsenic trioxide on Caenorhabditis elegans |
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| Authors: | Yan Yu Miao Zhao Lili Yu Xiaohong Pan Lingling Wu |
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| Institution: | 1. Medicine and Pharmacy Research Center, Binzhou Medical University, Yantai, China;2. Department of Life Sciences, Huainan Normal University, Huainan, China;3. Department of Life Sciences, Huainan Normal University, Huainan, China |
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| Abstract: | A Pseudomonas aeruginosa–Caenorhabditis elegans pathogenesis model was utilized to assess immunotoxic effects of arsenic trioxide (As2O3). After 2 h of As2O3 exposure, 500 µmol L?1 and 1 mmol L?1 As2O3 treatment significantly decreased median survivals of C. elegans (10 h after L4/adult molt). However, 2 h of As2O3 exposure caused no significant changes in the survivals rates of C. elegans (2 h after L4/adult molt). Notably, a significant dose-related immunoenhancement was observed in C. elegans (2 h after L4/adult molt) after 12 h of arsenite exposure. |
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| Keywords: | immunotoxicity arsenic Caenorhabditis elegans Pseudomonas aeruginosa fast-killing assay |
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