Obstetrical outcomes following amniocentesis performed after 24 weeks of gestation: A systematic review and meta-analysis |
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| Authors: | Ahmed A. Nassr Kamran Hessami Elena D’Alberti Antonella Giancotti Nazlisadat Meshinchiasl Mark I. Evans Daniele Di Mascio Alireza A. Shamshirsaz |
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| Affiliation: | 1. Department of Obstetrics & Gynecology, Baylor College of Medicine, Houston, Texas, USA;2. Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy;3. Comprehensive Genetics, PLLC, New York, New York, USA;4. Maternal Fetal Care Center, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA |
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| Abstract: | To evaluate obstetrical outcomes for women having late amniocentesis (on or after 24 weeks). Electronic databases were searched from inception to January 1st, 2023. The obstetrical outcomes evaluated were gestational age at delivery, preterm birth (PTB) < 37 weeks, PTB within 1 week from amniocentesis, premature prelabor rupture of membranes (pPROM), chorionamnionitis, placental abruption, intrauterine fetal demise (IUFD) and termination of pregnancy (TOP). The incidence of PTB <37 weeks was 4.85% (95% CI 3.48–6.56), while the incidence of PTB within 1 week was 1.42% (95% CI 0.66–2.45). The rate of pPROM was 2.85% (95% CI 1.21–3.32). The incidence of placental abruption was 0.91% (95% CI 0.16–2.25), while the rate of IUFD was 3.66% (95% CI 0.00–14.04). The rate of women who underwent TOP was 6.37% (95%CI 1.05–15.72). When comparing amniocentesis performed before or after 32 weeks, the incidence of PTB within 1 week was 1.48% (95% CI 0.42–3.19) and 2.38% (95% CI 0.40–5.95). Amniocentesis performed late after 24 weeks of gestation is an acceptable option for patients needing prenatal diagnosis in later gestation. |
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