Extractable organic matter of Standard Reference Material 1649a influences immunological response induced by pathogen-associated molecular patterns |
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| Authors: | Kerstin Ulrich Sabine Wölfle Anja Mayer Klaus Heeg Thomas Braunbeck Lothar Erdinger Holger Bartz |
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| Institution: | (1) Aquatic Ecology and Toxicology Group, Department of Zoology, University of Heidelberg, Im Neuenheimer Feld 230, 69120 Heidelberg, Germany;(2) Department of Hygiene and Medical Microbiology, Hygiene Institute, University of Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany;(3) Sanofi Pasteur MSD GmbH, Paul-Ehrlich-Str. 1, 69181 Leimen, Germany |
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| Abstract: | Background, aim, and scope Lungs are permanently and simultaneously challenged by airborne microorganisms and airborne pollutants. Temporal increase
of airborne particulate matter (APM), a potential carrier for extractable organic matter (EOM), degrades the situation of
pulmonary patients. The Ah receptor (AhR) has been described as an important factor influencing the immunological challenge
by viral infections. Molecular mechanisms underlying epidemiological observations are not well understood. Cytokine secretion
(IL-6, IL-8, and TGF-β) from human bronchial epithelial cells (Beas2B) was determined as an indicator for immune responses
upon co-stimulation with an artificial analog of viral dsRNA polyinosinic/polycytidylic acid, (PIC)] and EOM of Standard
Reference Material 1649a (SRM). Since polycyclic aromatic hydrocarbons are major components of APM usually acting via the
AhR, particular focus was on AhR involvement. |
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