| 微羹藻毒素诱导细胞凋亡的相关信号通路研究进展 |
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| 引用本文： | 邵迎,吴玲玲.微羹藻毒素诱导细胞凋亡的相关信号通路研究进展[J].四川环境,2011,30(6):128-132. |
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| 作者姓名： | 邵迎 吴玲玲 |
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| 作者单位： | 同济大学环境科学与工程学院教育部长江水环境重点实验室,上海,200092 |
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| 基金项目： | 教育部重点实验室自主研究课题——藻毒素对肝细胞的毒性作用与机制研究(YRWERY1008) |
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| 摘 要： | 细胞凋亡是微蓑藻毒素（Mycrocystins，MCs）发挥其毒性效应的关键所在，但其具体毒性作用机制目前尚未明确，有关MCs诱导细胞凋亡机制的研究仍然是当前的热点。已有研究表明，MCs诱导细胞凋亡是通过多条信号通路来转导的，各通路间互相联系，共同调节细胞凋亡。本文总结了近年来MCs诱导细胞凋亡的相关信号通路的研究进展，以期为全面阐述MCs诱导细胞凋亡的信号传导通路机制奠定基础。
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| 关 键 词： | 微蓑藻毒素 细胞凋亡 线粒体通路 死亡受体通路 内质网通路 |
Research Progress of Signal Pathways of Mycrocystins Inducing Cell Apoptosis |
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| SHAO Ying,WU Ling-ling.Research Progress of Signal Pathways of Mycrocystins Inducing Cell Apoptosis[J].Sichuan Environment,2011,30(6):128-132. |
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| Authors: | SHAO Ying WU Ling-ling |
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| Institution: | SHAO Ying,WU Ling-ling(Key Lab.of Yangtze River Water Environment,Ministry of Education,College of Environmental Science & Engineering,Tongji Univ.,Shanghai 200092,China) |
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| Abstract: | Apoptosis essentially results from the toxic effects of Mycrocystins(MCs),but the mechanism is still unclear,so it's still the focus of current research.Studies have shown that MCs induce apoptosis through several signal pathways which communicate each other to regulate apoptosis coordinately.This paper reviewed the research progress of MCs inducing apoptosis signal pathway so as to lay a foundation for full explanation of the mechanism of apoptosis induced by MCs. |
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| Keywords: | Mycrocystins Apoptosis mitochondrial pathway death receptor pathway endoplasmic reticulum pathway |
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