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Magnetically treated water at 4?Hz and 2.5?mT as a modulator of cisplatin effect on cell hydration and ouabain binding of sarcoma-180 tissue |
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| Authors: | L R Yeganyan R E Muradyan F H Arsenyan G K Bazikyan S N Ayrapetyan |
| Institution: | 1. Life Sciences International Postgraduate Educational Center, Yerevan, Armenia 2. NAS RA the Scientific Technological Center of Organic and Pharmaceutical Chemistry SNPO, Yerevan, Armenia 3. National Center of Oncology, Yerevan, Armenia |
| Abstract: | There are many data about the extremely low-frequency electromagnetic fields (ELF-EMF) therapeutic use, especially in the field of oncology. Recent data suggest that 4 Hz EMF having dehydration effect on tissues has a pronounced antitumor activity on sarcoma-180 in mice. It was shown that 4 Hz EMF have pronounced effects on physicochemical properties of water and water solution. Therefore, the aim of the present work was the comparative study of the modulation effect of ELF-EMF on cisplatin-induced changes cell hydration and number of ouabain receptors in membrane of sarcoma-180 tumor tissues. Tissue hydration was measured as wet weight/dry weight and expressed as a water content of g/g in dry weight. The number of 3H-ouabain receptors in membrane was counted by isotope scintillation counter. In conclusion, ELF-EMF can be a possible tool for stimulation of cisPt antitumor effect. |
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