Interaction of nano-TiO2 with lysozyme: insights into the enzyme toxicity of nanosized particles |
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| Authors: | Xu Zhen Liu Xi-Wei Ma Yin-Sheng Gao Hong-Wen |
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| Institution: | (1) State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai, 200092, China;(2) Department of Chemistry, Tongji University, Shanghai, 200092, China;(3) Environmental Engineering College, Nanjing Forestry University, Nanjing, 210037, China; |
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| Abstract: | Background, aim, and scope Nanomaterials have been used increasingly in industrial production and daily life, but their human exposure may cause health
risks. The interactions of nanomaterial with functional biomolecules are often applied as a precondition for its cytotoxicity
and organ toxicity where various proteins have been investigated in the past years. In the present study, nano-TiO2 was selected as the representative of nanomaterials and lysozyme as a representative for enzymes. By investigating their
interaction by various instrumentations, the objective is to identify the action sites and types, estimate the effect on the
enzyme structure and activity, and reveal the toxicity mechanism of nanomaterial. |
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