Sequential participation of glutathione and sulph-hydryl(s) in reductive dechlorination of 2,4-di-, and 2,4,5-trichloro phenacyl chlorides by soluble fraction (105,000 x g) of chicken liver homogenate. |
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Authors: | M H Akhtar |
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Abstract: | The mode of reductive dechlorination of alpha-chloroacetophenones, 2,4-di-, and 2,4,5-trichloro phenacyl chlorides into respective acetophenone by soluble fraction (105,000 x g) from chicken liver homogenate has been investigated. The transformation involved the sequential participation of glutathione and a sulph-hydryl. The phenacyl chloride first reacted with glutathione to yield the phenacyl glutathione, which in turn, in the presence of a sulph-hydryl, was reduced enzymatically to produce the ketone, probably via a disulfide intermediate. |
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