Evaluation of the mutagenic potential of some compounds using Salmonella typhimurium

The mutagenicity of sodium nitrite, potassium chromate, O-tolidine, and smoke condensate from tobacco was shown on Salmonella typhimurium TA 1535. Sodium nitrite was definitely mutagenic on TA 1535 without S-9 mix. Potassium chromate without S-9 mix was also mutagenic on TA 1535. However, addition of S-9 mix resulted in a complete loss of potassium chromate mutagenicity. O-tolidine with and without S-9 mix elicited a very weak and variable mutagenic effect for strain TA 1535. Smoke condensate from pipe tobacco without S-9 mix elicited a weak mutagenic effect, whereas with S-9 mix it showed no mutagenicity on TA 1535.