| 彗星试验检测酚类化合物对小鼠脾脏细胞DNA损伤的研究 |
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| 引用本文： | 孙立伟,吴 笛,曲甍甍,陈源高,吴玉璘,孔志明,刘征涛. 彗星试验检测酚类化合物对小鼠脾脏细胞DNA损伤的研究[J]. 环境科学研究, 2003, 16(1): 34-36 |
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| 作者姓名： | 孙立伟 吴 笛 曲甍甍 陈源高 吴玉璘 孔志明 刘征涛 |
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| 作者单位： | 1.南京大学,环境学院,污染控制与资源化研究国家重点实验室,江苏,南京,210093 |
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| 基金项目： | 国家自然科学基金资助项目 ( 2 99770 2 0 ) |
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| 摘 要： | 应用彗星试验技术,研究了酚类化合物对小鼠脾脏细胞DNA的损伤作用,试验结果表明,12种酚类化合物对小鼠脾脏细胞均能引起不同程度的DNA损伤,并呈现剂量效应关系.与对照组相比,均有显著性差异(P＜0 05,P＜0 01).试验结果亦表明,其DNA的损伤程度与化学结构有一定的关系.
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| 关 键 词： | 小鼠脾脏细胞 彗星试验 DNA损伤 |
| 文章编号： | 1001-6929(2003)01-0034-03 |
| 收稿时间： | 2002-05-30 |
Study on DNA Damage of Spleen Cell in Mice lnduced by Hydroxybenzene Compounds |
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| SUN Li-wei,WU Di,QU Men-men,CHEN Yuan-gao,WU Yu-lin,KONG Zhi-ming and LIU Zheng-tao. Study on DNA Damage of Spleen Cell in Mice lnduced by Hydroxybenzene Compounds[J]. Research of Environmental Sciences, 2003, 16(1): 34-36 |
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| Authors: | SUN Li-wei WU Di QU Men-men CHEN Yuan-gao WU Yu-lin KONG Zhi-ming LIU Zheng-tao |
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| Affiliation: | 1.State Key Laboratory of Pollution Control and Resource Reuse,Environmental School,Nanjing University,Nanjing 210093,China2.Chinese Research Academy of Environmental Sciences,Beijing 100012,China |
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| Abstract: | The comet assay was used to detect the DNA damage of spleen cells in mice,which were induced by 12 tested hydroxybenzene compounds.The results showed that all the 12 tested substances could induce different levels of DNA damage.The dose-response relations were obvious.Compared with the control group,all the treated groups were significantly different (P<0.05,P<0.01).It was also shown that the degree of DNA damages was partly related to the structure of hydroxybenzene compounds. |
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| Keywords: | spleen cell of mice comet assay DNA damage |
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