鸡贫血病毒的分子生物学研究进展

鸡贫血病毒 (ｃｈｉｃｋｅｎａｎｅｍｉａｖｉｒｕｓ,ＣＡＶ)是鸡传染性贫血病 (ｃｈｉｃｋｅｎｉｎｆｅｃｔｉｏｕｓａｎｅｍｉａ,ＣＩＡ)的主要病原 .ＣＡＶ感染可引起雏鸡骨髓造血组织和胸腺等淋巴组织萎缩 ,从而导致严重贫血 ,甚至造成死亡1] ;同时ＣＡＶ感染还能导致免疫抑制2～ 7] .自 1979年日本学者Ｙｕａｓａ等8] 首次报道该病毒以来 ,西德、瑞典、英国、丹麦、波兰、美国、澳大利亚、荷兰、巴西和阿根廷等国先后发现该病毒的存在9～ 11] .我国于 1992年首次在黑龙江省分离到ＣＡＶ12 ] ,随后在河南、山东、江苏、辽宁、吉林…

MOLECULAR BIOLOGICAL PROGRESSION OF CHICKEN ANEMIA VIRUS(CAV)

Chicken anemia virus (CAV) is the main pathogen of chicken infectious anemia (CIA). It is widespread all over the world and becomes one of the main pathogens affecting poultry industry seriously. CAV genome contains three partially overlapped genes, vp1, vp2 and vp3, which encode three kinds of proteins, VP1, VP2 and VP3, respectively. VP1 related to its antigenicity is the only capsid protein of CAV; VP2 might act as a scaffold protein to help VP1 form correct conformation; and VP3, also named apoptin, is related to the pathogenicity of CAV, and is proved by some experimental data to have low acute toxicity and is effective as an anti-tumor agent. According to the molecular biological progression of CAV research, three questions reviewed in this paper are (1) the classification status of CAV, (2) CAV genomic structure, and (3) the encoded proteins (VP1, VP2 and VP3) of CAV genome. Ref 31