硒镉联合作用对大、小鼠精子畸形率的影响

通过对小鼠腹腔注射硒、镉化合物和大鼠经口摄入低硒加镉粮，来观察高剂量镉，高、低剂量硒单独和联合作用的遗传学效应。结果表明，不仅氯化镉和亚硒酸钠能引起精子畸形率的明显升高，长期摄入低硒粮也能引起精子畸形率的明显升高。当高硒高镉联合作用时，亚硒酸钠可明显对抗氯化镉的遗传毒性，而低硒高镉联合作用时，则加重了氯化镉和亚硒酸钠的遗传毒性。

THE COMBINED EFFECT OF SELENIUM AND CADMIUM ON THE RATES OF SPERM ABNORMALITY IN RATS AND MICE

The genetic effects of combined exposure to Se and Cd Were evaluated in mice intraperitoneally treated with selenium and cadmium at high dose level and in rats fed a selenium-deficient diet supplemented with high level of cadmium.The results showed that significant increases in sperm apnormality rate could be induced not only at high level of Se and Cd but also at low level of Se.Sodium selenite had strong inhibitory effect on the genotoxicity of cadmium chloride when the compounds interact on each other.In comparison with exposure to Se and Cd alone,combined exposure to low level of Se and high level of Cd could lead to stronger genotoxicity.