静脉注射多壁碳纳米管后大鼠脏器的病理学观察(Pathological Observations of Rat Tissues After Intravenous Injection of Mutil-Wall Carbon Nanotubes)

以Wistar大白鼠为研究对象,观察了多壁碳纳米管(MWNTs)体内暴露后脏器的病理学变化.采用尾静脉注射的方法将直径为40～60nm的多壁碳纳米管(40～60MWNTs)和直径小于10nm的多壁碳纳米管(10MWNTs)暴露于大白鼠体内,同时分别采用纳米二氧化硅(SiO2)和乙炔碳黑(Cb)作为阳性和阴性对照.实验结果表明:1、3、5mg·kg-1(以大鼠体重计)多壁碳纳米管进入大鼠体内90d后,大鼠心脏、肾脏、肝脏和胃结构正常,未见明显的病理损伤.但是多壁碳纳米管均可在大鼠肺部沉积,随着暴露时间的延长,多壁碳纳米管一部分被肺巨噬细胞清除体外,但是残余的多壁碳纳米管引起了肺部的病理学改变.

Pathological Observations of Rat Tissues After Intravenous Injection of Mutil-Wall Carbon Nanotubes

Different sizes(40～60nm; <10nm)mutil-wall carbon nanotubes(MWNTs)were exposed into Wistar rats using intravenous injection administration modes. Nano-silica(SiO2)and acetylene carbon black(Cb)were used as the positive and negative control, respectively. The results show that obvious histopathologic changes have been observed in the structure of lung tissue, when 1, 3, 5mg·kg-1 carbon nanotubes was put into the body of rats, however, other tissues of rats including kidney, liver and stomach are almost in normal. Although enormous differences are in lung between rodent animals and human beings, the potential risk of exposure to MWNTs needs to pay attention.