Distribution of radiotin (Sn) in partially hepatectomised rats and its binding with subcellular components of liver cells

Distribution of radiotin (Sn¹¹³) in target organs and in the hepatic subcellular fractions was studied in sham and partially hepatectomised rats 72 hrs after the administration of tin (II) tartrate (2 mg Sn⁺⁺, 10 uCi/100 gm body weight) intraperitoneally. The results indicate that in both the groups Sn¹¹³ was maximally accumulated in liver followed by kidney and spleen. Partially hepatectomised rat however accumulated less Sn¹¹³ in liver while an increase was observed in kidney. Subcellular studies showed significantly high affinity of tin for microsomes. A compartmental shift of radiotin from cytosol to microsomal fraction was observed in hepatectomised rats when compared to sham operated rats.