| The damage effects of oxy free radicals and fulvic acid on chondrocytes |
| |
| 作者姓名： | Zhang Fahao Wang Kui Xu Shanjin |
| |
| 作者单位： | Zhang Fahao，Wang Kui and Xu ShanjinSchool of Pharmaceutical Sciences and research Laboratones of Natural and Biomimetic Drugs.Beijing Medical Universi-ty，Beijing，100083，China |
| |
| 摘 要： | The damage effects of oxy free radical and fulvic acid on cultivated chicken embryo chondrocytes were studied. The results show that the growrth of chondrocytes is inhibited and the morphology of the cells altered. The collagen synthesizing capability of the damaged cell changes somewhat. A noteworthy change of the type of collagen synthesized by the abnormal cells was observed by CMC-chromatography and amino acid analysis. The results indicated that the abnonml cells tend to synthesize type I instead of type II collagen, which is synthesized and secreted by the intact chondrocyte.
|
| 关 键 词： | free radical fulvic acid chondrocyte collagen Kaschin-Beck disease. |
| 收稿时间： | 1991/7/11 0:00:00 |
The damage effects of oxy free radicals and fulvic acid on chondrocytes |
| |
| Zhang Fahao,Wang Kui,Xu Shanjin.The damage effects of oxy free radicals and fulvic acid on chondrocytes[J].Journal of Environmental Sciences,1991,3(4):48-54. |
| |
| Authors: | Zhang Fahao Wang Kui and Xu ShanjinSchool of Pharmaceutical Sciences and research Laboratones of Natural and Biomimetic Drugs |
| |
| Institution: | Zhang Fahao,Wang Kui and Xu ShanjinSchool of Pharmaceutical Sciences and research Laboratones of Natural and Biomimetic Drugs.Beijing Medical Universi-ty,Beijing,100083,China |
| |
| Abstract: | The damage effects of oxy free radical and fulvic acid on cultivated chicken embryo chondrocytes were studied. The results show that the growrth of chondrocytes is inhibited and the morphology of the cells altered. The collagen synthesizing capability of the damaged cell changes somewhat. A noteworthy change of the type of collagen synthesized by the abnormal cells was observed by CMC-chromatography and amino acid analysis. The results indicated that the abnonml cells tend to synthesize type I instead of type II collagen, which is synthesized and secreted by the intact chondrocyte. |
| |
| Keywords: | free radical fulvic acid chondrocyte collagen Kaschin-Beck disease |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《环境科学学报(英文版)》浏览原始摘要信息 |
| 点击此处可从《环境科学学报(英文版)》下载免费的PDF全文 |
