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Optimal feed profile for a second order reaction in a semi-batch reactor under safety constraints: Experimental study |
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| Authors: | Olivier Ubrich Balasubrahmanyan Srinivasan Pablo Lerena Dominique Bonvin Francis Stoessel |
| Affiliation: | a Institut de Génie Chimique, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland b Institut d'Automatique, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland c Novartis Services, presently Swiss Institute for the Promotion of Safety and Security, CH-4002 Basel, Switzerland |
| Abstract: | Maximising the yield of the second order reaction (2-butanol+propionic anhydride) by manipulating the inlet flow rate is considered for an isothermal semi-batch process. First a procedure for the determination of the kinetic parameters using coupled spectroscopic and calorimetric methods is presented. Then an optimisation of the reaction system is performed numerically and verified experimentally. Constraints on the amount of heat produced and on the temperature attainable in the case of cooling failure are imposed for safety consideration. |
| Keywords: | Kinetic parameters determination Semi-batch reaction system Safety constraints Dynamic optimisation |
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