植物药重金属污染状况及全链条生产过程污染的溯源与管控

植物药所含的重金属具有一定的健康风险,但目前缺少对植物药重金属污染状况、溯源及管控的系统研究.总结了世界范围内对植物药重金属的限量标准,依据《中国药典》2020年版的相关要求,基于Web of Science及中国知网(CNKI)数据库中获取的相关文献对国内外植物药的重金属含量进行了分析,结果表明:国外植物药重金属超标...

Pollution status of heavy metals in herbal medicine and their traceability & control in the whole chain production process

Heavy metals in herbal medicine have health risks, but currently systematic studies are lacking on their pollution status, source traceability and control. This paper summarizes the limit standards for heavy metals in herbal medicine in the world. According to the requirements of the Chinese Pharmacopoeia (2020 Version), the pollution status of heavy metals in herbal medicine is analyzed based on the relevant data obtained from the databases of Web of Science and CNKI. The results showed that the pollution in foreign countries is more serious than that in China, with a rate of 24.58% and 24.07% exceeding the standard, respectively. Lead, aresnic, and mercury are the most commonly found heavy metals in foreign countries and in China. In terms of time scale, the exceeding-standard rate of arsenic in Chinese herbal medicine has gradually increased over time, and that of mercury has gradually reduced. The exceeding-standard rates of copper and lead reached peaks in 2010—2015 and decreased afterwards; that of cadmium has not significantly changed since 2010. In terms of geographical distribution, northwest region is the area with the most serious heavy metal pollution in herbal medicine in China, followed by the southeast region. The whole chain production process of herbal medicine includes planting, processing and transportation-storage. Its source traceability and control measures was pointed out to provide the systematic and practicable strategies for reducing the health risks of heavy metals in herbal medicine.