双酚A类似物的雄性生殖毒性研究进展

聚焦BPA类似物对雄性动物的生殖毒性研究,分析双酚S、双酚F、双酚AF、双酚B和双酚E对哺乳类实验动物睾丸及组织结构、附睾重量及组织学结构、激素水平、精子参数等常规指标的影响,考察关于鱼类和两栖类动物的研究.研究发现,不管暴露剂量高低、暴露方式的差异或是动物种属的不同,所有BPA类似物的暴露都显示阳性结果,这与BPA雄...

Research progress in male reproductive toxicity of bisphenol A analogues

This paper examined studies on bisphenol analogues and male reproductive toxicity with the focus on analyzing the data involving toxic effects of bisphenol analogues on the testis and organization structure, weight and histological structure of epididymis, hormone levels and sperm parameters in mammals, and investigating several essays about fish and amphibian animal research. All BPA analogues had reproductive hazards in these animals regardless of dose, mode of exposure, or species of animals, which suggested that these BPA analogues had more significant male reproductive toxicity than that of BPA on which researches were still debating. However, the majority of data points on the male reproductive toxicity of BPA analogues was limited from a few laboratories and quality control was also hard to discern. Therefore, to obtain more reliable and repeatable results, the findings on male reproductive toxicity of BPA analogues need to be verified by more laboratories, and the quality of animal experiments should be strictly controlled.