Synthesis and antimicrobial activity of esters of 3-ethoxy-4-hydroxybenzaldehyde oxime |
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| Authors: | Vivek Ahluwalia Jitendra Kumar Virendra S Rana Rajendra Singh Om P Sati |
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| Institution: | 1. Division of Agricultural Chemicals, Indian Agricultural Research Institute, New Delhi, India;2. Department of Chemistry, HNB Garhwal University, Srinagar (Garhwal), India;3. Department of Chemistry, HNB Garhwal University, Srinagar (Garhwal), India |
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| Abstract: | A series of oxime esters was synthesized by esterification of 3-ethoxy-4-benzaldehyde oxime with acid chlorides in the presence of triethylamine. They were evaluated for their in vitro antifungal activity against three pathogenic fungi, namely Rhizoctonia bataticola, Fusarium udum, and Alternaria porii, and their antibacterial activity against the three bacterial strains Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumoneae. The compounds bearing medium-length alkyl chains showed greater activity than those with long alkyl chains. An electron-donating group in para position of the aryl ring confers highest activity. |
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| Keywords: | Oxime esters antifungal activity antibacterial activity |
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