Exposure and body burden of polychlorinated biphenyls (PCB) and metals in a historically contaminated community |
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| Affiliation: | 1. Department of Clinical and Experimental Medicine, Linkoping University, Department of Occupational and Environmental Medicine, County Council of Ostergotland, Linkoping, Sweden;2. MTM Research Centre, School of Science and Technology, Orebro University, Orebro, Sweden;3. Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden;4. Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden;1. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA;2. Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA;3. Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD, USA;4. Kidney Institute and Division of Nephrology, Department of Internal Medicine, China Medical University Hospital and College of Medicine, China Medical University, Taichung, Taiwan;5. Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA;6. Division of Pediatric Nephrology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA;7. Department of Environmental and Occupational Health, University of North Texas Health Science Center, Fort Worth, TX, USA;1. Food Research Division, Bureau of Chemical Safety, Health Products and Food Branch, Health Canada, Sir Frederick Banting Research Centre, 251 Sir Frederick Banting Driveway, 2203C, Tunney''s Pasture, Ottawa, ON K1A 0K9, Canada;2. Environmental Health Science and Research Bureau, Environmental and Radiation Health Sciences Directorate, Healthy Environments and Consumer Safety Branch, Health Canada, 50 Colombine Driveway, 0801A, Ottawa, ON K1A 0K9, Canada;3. CHU Sainte-Justine, Centre de recherche, Université de Montréal, Montréal, QC, Canada |
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| Abstract: | There are many small villages where environmental contamination is substantial due to historical industrial activities. The aim of the present study was to investigate if long-term or current consumption of local foods, as reported in food frequency questionnaires, co-vary with measured concentrations of polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), lead (Pb), cadmium (Cd) and mercury (Hg) in blood, urine and hair from a population living in a historically contaminated village.Blood, urine and hair were provided by men (n = 38) and women (n = 57), who had participated in a previous case–control study in the contaminated area, and were analyzed for PCB, OCPs, Pb, Cd and Hg. A detailed food frequency questionnaire, used in the previous epidemiological study, was repeated, and up-dated information of life-style, exposure factors and other covariates was collected. Associations between reported consumption of local foods and exposure biomarkers were explored in relation to age, gender, life-style factors and other covariates.A large part of the population in the area reported consumption of local food, and thus, was potentially exposed to the contaminants. Despite the limited number of participants and other weaknesses described, it was possible to link reported consumption of different foods to biomarker concentrations.Reported consumption of local vegetables, forest berries and mushrooms co-varied with urinary Cd, indicating an influence from the contaminated area on the Cd exposure. We found no associations between PCB plasma concentrations with reported consumption of local fish, but with consumption of herring (non-local sea fish) which is typically high in PCB. Pesticide (HCB, p,p′-DDE, trans-nonachlor) exposure was mainly associated with agricultural work and having a private well the first five years of life, but we found no associations between pesticide concentrations in plasma and consumption of local vegetables or fish. Exposure to Hg was associated with consumption of fish, both local and non-local, and Pb exposure was associated with the consumption of game.Overall, the contaminant concentrations measured in blood, urine and hair varied substantially among study participants, but on average, the concentrations were similar to concentrations measured in other groups of the general Swedish population in the same age range. Larger studies are needed to evaluate health risks (and causality) associated with historical environmental contamination. |
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