Prenatal and early-life polychlorinated biphenyl (PCB) levels and behavior in Inuit preschoolers |
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| Institution: | 1. Department of Environmental Health, Harvard School of Public Health, 401 Park Drive, HSPH-BWH-301W, Boston, MA 02215, USA;2. Institute of Environmental Medicine, Karolinska Institutet, Box 210, Nobelsväg 13, Solna 171 77, Sweden;3. Centre for Studies on Human Stress, Research Center of the Mental Health Institute, 7401 Rue Hochelaga, Montreal, Quebec, H1N 3M5, Canada;4. Etholabs, School of Psychoeducation, University of Montreal, C. P. 6128, succursale Centre-ville, Montreal, Quebec, H3C 3J7, Canada;5. Département de psychologie, Université du Québec à Montréal, 320 Sainte-Catherine Est Pavillon J.A. De Sève, local DS5775, Montreal, Quebec H2X 1L7, Canada;6. INSERM U1085, Université Rennes I, 263 Avenue du Général Leclerc, 35042 Rennes, France;7. Department of Occupational and Environmental Health, School of Public Health, Université de Montréal, 2375 ch. de la Cote-Sainte-Catherine, Montreal, Quebec, H3T 1A8, Canada;8. Université de Montréal Public Health Research Institute, Université de Montréal, 7101 avenue du Parc, office 3187-03, Montreal, Quebec, H3N 1X9, Canada;9. Centre de recherche du CHU de Québec, Université Laval, 2875 Laurier, Quebec, Quebec G1V 2M2, Canada;1. Educational Psychology and Methodology, University at Albany, 1400 Washington Ave., Albany, NY 12222, USA;2. School Psychology, University at Albany, 1400 Washington Ave., Albany, NY 12222, USA;3. Department of Anthropology, 1400 Washington Ave., Albany, NY 12222, USA;4. Center for the Elimination of Minority Health Disparities, 1400 Washington Ave., NY 12222, USA;5. Department of Epidemiology and Biostatistics, School of Public Health, One University Place, Rensselaer, NY, USA;6. Akwesasne Mohawk Nation;1. Qingdao Centers for Disease Control and Prevention, Qingdao 266033, China;2. Department of Hygiene Analysis and Detection, School of Public Health, Nanjing Medical University, Nanjing 211166, China;3. Institute of Child Health Care, Nanjing Maternity and Child Health Care Hospital, Nanjing 210004, China;4. Department of Child Health Care, Maternity and Child Care Center of Gulou District of Nanjing, Nanjing 210029, China;5. Department of Occupational Medicine and Environmental Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China;1. Centre for Fetal Programming, Department of Epidemiology Research, Statens Serum Institut, DK-2300 Copenhagen S, Denmark;2. Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA;3. Department of Exposure and Risk Assessment, Norwegian Institute of Public Health, NO-0406 Oslo, Norway;4. Department of Environmental Health, National Institute for Health and Welfare, FI-70701 Kuopio, Finland;5. Faculty of Food Science and Nutrition, University of Iceland, IS-101 Reykjavik, Iceland;6. Unit for Nutrition Research, Landspitali University Hospital, IS-101 Reykjavik, Iceland |
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| Abstract: | BackgroundWhereas it is well established that prenatal exposure to polychlorinated biphenyls (PCBs) can disrupt children's behavior, early postnatal exposure has received relatively little attention in environmental epidemiology.ObjectivesTo evaluate prenatal and postnatal exposures to PCB-153, a proxy of total PCB exposure, and their relation to inattention and activity in 5-year-old Inuits from the Cord Blood Monitoring Program.MethodsPrenatal exposure to PCBs was informed by cord plasma PCB-153 levels. We used a validated pharmacokinetic model to estimate monthly infants' levels across the first year of life. Inattention and activity were assessed by coding of video recordings of children undergoing fine motor testing. We used multivariable linear regression to evaluate the association between prenatal and postnatal PCB-153 levels and inattention (n = 97) and activity (n = 98) at 5 years of age.ResultsCord plasma PCB-153 was not associated with inattention and activity. Each interquartile range (IQR) increase in estimated infant PCB-153 levels at 2 months was associated with a 1.02% increase in the duration of inattention (95% CI: 0.04, 2.00). Statistical adjustment for the duration of breastfeeding slightly increased regression coefficients for postnatal level estimates, some of which became statistically significant for inattention (months: 2–4) and activity (months: 2–5).ConclusionsOur study adds to the growing evidence of postnatal windows of development during which children are more susceptible to neurotoxicants like PCBs. |
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