Arsenic exposure,hyperuricemia, and gout in US adults |
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| Institution: | 1. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA;2. Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA;3. Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD, USA;4. Kidney Institute and Division of Nephrology, Department of Internal Medicine, China Medical University Hospital and College of Medicine, China Medical University, Taichung, Taiwan;5. Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA;6. Division of Pediatric Nephrology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA;7. Department of Environmental and Occupational Health, University of North Texas Health Science Center, Fort Worth, TX, USA;1. Department of Clinical and Experimental Medicine, Linkoping University, Department of Occupational and Environmental Medicine, County Council of Ostergotland, Linkoping, Sweden;2. MTM Research Centre, School of Science and Technology, Orebro University, Orebro, Sweden;3. Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden;4. Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden;1. UNSW Water Research Centre, School of Civil and Environmental Engineering, University of New South Wales, Kensington, NSW 2052, Australia;2. Nanotechnology and Integrated BioEngineering Centre, School of Engineering, University of Ulster, Jordanstown, County Antrim BT37 0QB, Northern Ireland, United Kingdom;1. Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, FISABIO-Public, Health, Valencia, 21, Avenida Catalunya, 46020 Valencia, Spain;2. Laboratory of Public Health of Valencia, 21 Avenida Catalunya, 46020 Valencia, Spain;3. Department of Analytical Chemistry, Faculty of Chemistry, University of Valencia, 50 Doctor Moliner, 46100 Burjassot, Spain;4. Laboratory of Public Health of Alicante, 6 Plaza España, 03010 Alicante, Spain;5. Analytical Unit, Health Research Institute La Fe, Avenida Abril Martorell, 106, 46026 Valencia, Spain;1. Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China;2. Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, China;3. State Key Lab of Reproductive Medicine, Institute of Toxicology, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, China |
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| Abstract: | BackgroundThere is very limited information on the association between arsenic and serum uric acid levels or gout. The aim of this study was to investigate the association of arsenic with hyperuricemia and gout in US adults.MethodsA cross-sectional study was conducted in 5632 adults aged 20 years or older from the National Health and Nutrition Examination Survey (NHANES) 2003–2010 with determinations of serum uric acid and urine total arsenic and dimethylarsinate (DMA). Hyperuricemia was defined as serum uric acid higher than 7.0 mg/dL for men and 6.0 mg/dL for women. Gout was defined based on self-reported physician diagnosis and medication use.ResultsAfter adjustment for sociodemographic factors, comorbidities and arsenobetaine levels, the increase in the geometric means of serum uric acid associated with one interquartile range increase in total arsenic and DMA levels was 3% (95% CI 2–5) and 3% (2–5), respectively, in men and 1% (0–3) and 2% (0–4), respectively, in women. In men, the adjusted odds ratio for hyperuricemia comparing the highest to lowest quartiles of total arsenic was 1.84 (95% CI, 1.26–2.68) and for DMA it was 1.41 (95% CI, 1.01–1.96). The corresponding odds ratios in women were 1.26 (0.77, 2.07) and 1.49 (0.96, 2.31), respectively. The odds ratio for gout comparing the highest to lowest tertiles was 5.46 (95% CI, 1.70–17.6) for total arsenic and 1.98 (0.64–6.15) for DMA among women older than 40 years old. Urine arsenic was not associated with gout in men.ConclusionLow level arsenic exposures may be associated with the risk of hyperuricemia in men and with the prevalence of gout in women. Prospective research focusing on establishing the direction of the relationship among arsenic, hyperuricemia, and gout is needed. |
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