Perfluoroalkyl substances (PFAS) including structural PFOS isomers in plasma from elderly men and women from Sweden: Results from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) |
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| Institution: | 1. Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, SE-751 83 Uppsala, Sweden;2. MTM Research Centre, School of Science and Technology, Örebro University, SE-701 82 Örebro, Sweden;3. Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University Hospital, SE-751 85 Uppsala, Sweden;4. Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University Hospital, SE-751 85 Uppsala, Sweden;1. Department of Environmental Chemistry, NILU — Norwegian Institute for Air Research, Fram Centre, Hjalmar Johansens Gate 14, NO-9296 Tromsø, Norway;2. Department of Community Medicine, Faculty of Health Sciences, University of Tromsø–The Arctic University of Norway, Sykehusveien 44, NO-9037 Tromsø, Norway;3. Department of Laboratory Medicine, Diagnostic Clinic, University Hospital of North Norway, Sykehusveien 38, NO-9038 Tromsø, Norway;4. Department of Applied Environmental Science, ITM, Stockholm University, SE-106 91 Stockholm, Sweden;5. Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada;1. The Hamner Institutes for Health Sciences, RTP, NC, USA;2. Department of Environmental Health, Harvard School of Public Health, Boston, USA;3. US Environmental Protection Agency, RTP, NC, USA;4. National Institute of Environmental Health Sciences, RTP, NC, USA;1. ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain;2. Universitat Pompeu Fabra (UPF), Barcelona, Spain;3. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain;4. FISABIO Universitat de València–Universitat Jaume I Joint Research Unit, Valencia, Spain;5. Subdirección de Salud Pública y Adicciones de Gipuzkoa, Donostia-San Sebastián, Spain;6. Instituto de Investigación Sanitaria BIODONOSTIA, Donostia-San Sebastián, Spain;7. Institute for Occupational Medicine, RWTH Aachen University, Aachen, Germany;8. Universidad Miguel Hernandez, San Juan de Alicante, Spain |
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| Abstract: | Per- and polyfluoroalkyl substances (PFASs) are a class of compounds with unique chemical properties that have been shown useful in a wide variety of applications because they provide materials with reduced surface tension and exceptional non-stick properties. PFASs are commonly found in impregnation materials, coatings of papers and textiles, fire-fighting foams, pesticides, and cleaning agents. The potential for human exposure to PFASs is high because of their widespread distribution. The aim of this study was to investigate levels of PFASs in men and women from Sweden and to assess the influence of gender and parity among women. Levels of 13 PFASs were determined in plasma samples collected during 2001–2004 from 1016 (507 women) 70 year-old participants from the population-based Prospective Study of the Vasculature in Uppsala Seniors (PIVUS). The PFASs studied were nine perfluorinated carboxylic acids (PFCAs), four perfluorinated sulfonic acids (PFSAs) and perfluorooctane sulfonamide (PFOSA). In addition, structural isomers of perfluorooctane sulfonic acid (PFOS) were determined in a subset of 398 individuals. The detection rates were high and the majority of the studied compounds were detected in more than 75% of the participants. Levels of the selected analytes were found to be similar to other studies of non-occupationally exposed populations. Gender differences were observed in levels of PFHpA which was higher in men, while PFHxS was higher in women. Parity among women was shown to have a minor effect on PFAS concentrations and we found primi- and multiparous women to have slightly lower levels of PFUnDA when compared to nulliparous women. |
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