Associations of birth outcomes with maternal polybrominated diphenyl ethers and thyroid hormones during pregnancy |
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| Institution: | 1. School of Natural Resources and Environment, University of Michigan, Ann Arbor, MI 48109, USA;2. Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA;3. Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI 48109, USA;4. National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA;5. Nicholas School of the Environment, Duke University, Durham, NC 27708, USA;1. Section of Cardiology, Medstar Washington Hospital Center/Georgetown University, Washington, DC, United States;2. Lifespan Cardiovascular Institute, Providence, RI, United States;3. Warren Alpert Medical School of Brown University, Providence, RI, United States;4. Department of Neurology, University of Maryland, Baltimore, MD, United States |
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| Abstract: | BackgroundPrevious research has linked polybrominated diphenyl ether (PBDE) exposure to poor birth outcomes and altered thyroid hormone levels.ObjectivesWe examined whether maternal PBDE serum levels were associated with infant birth weight (g), head circumference (cm), birth length (cm), and birth weight percentile for gestational age. We explored the potential for a mediating role of thyroid hormone levels.MethodsDuring 2008–2010, we recruited 140 pregnant women in their third trimester as part of a larger clinical obstetrics study known as Healthy Pregnancy, Healthy Baby. Blood samples were collected during a routine prenatal clinic visit. Serum was analyzed for PBDEs, phenolic metabolites, and thyroid hormones. Birth outcome information was abstracted from medical records.ResultsIn unadjusted models, a two-fold increase in maternal BDE 153 was associated with an average decrease in head circumference of 0.32 cm (95% CI: − 0.53, − 0.12); however, this association was attenuated after control for maternal risk factors. BDE 47 and 99 were similarly negatively associated but with 95% confidence intervals crossing the null. Associations were unchanged in the presence of thyroid hormones.ConclusionsOur data suggest a potential deleterious association between maternal PBDE levels and infant head circumference; however, confirmatory studies are needed in larger sample sizes. A mediating role of thyroid hormones was not apparent. |
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