Perfluoroalkyl substances measured in breast milk and child neuropsychological development in a Norwegian birth cohort study |
| |
| Institution: | 1. Department of Genes and Environment, Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway;2. Department of Exposure and Risk Assessment, Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway;3. Institute for Environmental Studies, Faculty of Earth and Life Sciences, VU University, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands;4. Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway;1. Unit Environmental Risk and Health, Flemish Institute for Technological Research (VITO), Mol, Belgium;2. Department of Contaminants, Diet and Microbiota, Infection Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway;3. Slovak Medical University, Faculty of Public Health, Department of Environmental Medicine, Bratislava, Slovakia;4. Department of Health and Life Sciences, VU University, Amsterdam, The Netherlands;5. ISGlobal, Barcelona, Spain;6. Pompeu Fabra University, Barcelona, Spain;7. Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain;8. Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre-Sophia Children''s Hospital, Rotterdam, The Netherlands;9. INSERM U1085 IRSET, Rennes, France;10. Institute for Environmental Studies (IVM), VU University, Amsterdam, The Netherlands;11. Department of Health Sciences, School of Medicine, University of California, Davis, USA;12. Epidemiology and Environmental Health Joint Research Unit, FISABIO–Universitat Jaume I–Universitat de València, Valencia, Spain;13. Department of Preventive Medicine and Public Health, University of Basque Country (UPV/EHU), Bilbao, Spain;14. Health Research Institute, Biodonostia, San Sebastian, Spain;15. Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Barcelona, Spain;p. Servicio de Salud de las Islas Baleares (IB-Salut), Area de Salut de Menorca, Balearic Islands, Spain;q. Public Health Laboratory in Gipuzkoa, Basque Government, San Sebastian, Spain;r. Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands;s. Division of Toxicology and Veterinary Pharmacology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands;t. Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium;u. University of Southern Denmark, Institute of Public Health, Department of Environmental Medicine, Odense, Denmark;1. Área de Toxicología, Universidad de Murcia, Campus de Espinardo, 30100 Murcia, Spain;2. University of Siena, Department of Physical Sciences, Earth and Environment, Via Mattioli, 4, 53100 Siena, Italy;3. Department of Legal Medicine, School of Medicine, University of Murcia & Instituto Murciano de Investigacion Biomedica (IMIB), (IMIB-VIRGEN DE LA ARRIXACA), Murcia, Spain;4. Department of Chemistry “Ugo Schiff”, via della Lastruccia 3, 50019 Sesto Fiorentino, Firenze, Italy;5. Bioscience Research Center, Via Aurelia Vecchia 32, 58015 Orbetello, GR, Italy;1. Division of Epidemiology, Department of Environmental Health, University of Cincinnati College of Medicine, P.O. Box 670056, Cincinnati, OH 45267, USA;2. Department of Epidemiology, Brown University School of Public Health, 121 South Main St, Box G-S121-2, Providence, RI 02912, USA;3. Division of General and Community Pediatrics, Cincinnati Children''s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, MLC 7035, Cincinnati, OH 45229, USA;4. Division of Biostatistics and Bioinformatics, Department of Environmental Health, University of Cincinnati College of Medicine, 160 Panzeca Way, Cincinnati, OH 45267, USA;5. BC Children''s Hospital Research Institute and Faculty of Health Sciences, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A 1S6, Canada;6. Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA;1. Center for Environmental Research and Children''s Health, University of California, Berkeley School of Public Health, Berkeley, CA, USA;2. Division of Epidemiology, University of California, Berkeley School of Public Health, Berkeley, CA, USA;3. Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA;4. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA;5. Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA;6. Department of Neurology, Boston Children''s Hospital, Harvard Medical School, Boston, MA, USA;7. Department of Environmental Health, Boston University School of Public Health, Boston, MA, USA |
| |
| Abstract: | Perfluoroalkyl substances (PFASs) are chemicals with potential neurotoxic effects although the current evidence is still limited. This study investigated the association between perinatal exposure to perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) and neuropsychological development assessed at 6, 12 and 24 months. We measured PFOS and PFOA in breast milk samples collected one month after delivery by mothers of children participating in the HUMIS study (Norway). Cognitive and psychomotor development was measured at 6 and at 24 months using the Ages and Stages Questionnaire (ASQ-II). Behavioral development was assessed using the infant–toddler symptom checklist (ITSC) at 12 and at 24 months. Weighted logistic regression and weighted negative binomial regression models were applied to analyze the associations between PFASs and ASQ-II and ITSC, respectively. The median concentration of PFOS was 110 ng/L, while the median for PFOA was 40 ng/L. We did not detect an increased risk of having an abnormal score in ASQ-II at 6 months or 24 months. Moreover, no consistent increase in behavioral problems assessed at 12 and 24 months by ITSC questionnaire was detected. We observed no association between perinatal PFOS and PFOA exposure and early neuropsychological development. Further longitudinal studies are needed to confirm the effects of these compounds on neuropsychological development in older children. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
