Effect of sub-acute exposure to TiO2 nanoparticles on oxidative stress and
histopathological changes in Juvenile Carp (Cyprinus carpio) |
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Authors: | HAO Linhu WANG Zhenyu and XING Baoshan |
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Institution: | 1. College of Environmental Science and Engineering, Ocean University of China, Qingdao 266100, China;First Institute of Oceanography, State Oceanic Administration, Qingdao 266061, China 2. College of Environmental Science and Engineering, Ocean University of China, Qingdao 266100, China 3. College of Environmental Science and Engineering, Ocean University of China, Qingdao 266100, China;Department of Plant, Soil and Insect Sciences, University of Massachusetts, Amherst MA01003, USA |
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Abstract: | Increasing application of nanotechnology highlights the need to clarify and understand nanotoxicity. Mammalian and in vitro studies
have raised concerns about the toxicity of titanium dioxide nanoparticles (TiO2-NPs), but there are limited data on ecotoxicity to
aquatic organisms. In this work, the sub-acute toxicity of TiO2-NPs to carp (Cyprinus carpio) was assessed. Superoxide dismutase
(SOD), catalase (CAT) and peroxidase (POD) activities and lipid peroxidation (LPO) levels in liver, gill and brain tissues of carps
varied with concentration of TiO2-NPs suspensions and exposure time (up to 8 d). As a result, 100 and 200 mg/L TiO2-NPs caused
statistically significant decrease in SOD, CAT and POD activities and significant increase in LPO levels in tissues (P < 0.05), suggesting
that the fish exposed to these two concentrations of TiO2-NPs su ered from the oxidative stress. The extent of depletion of antioxidant
enzymes activities and the elevation of LPO in the liver was the greatest, indicating that the liver might be the most susceptible organ
to TiO2-NPs exposure. In addition, carps had gill pathologies including edema and thickening of gill lamellae as well as gill filaments,
and liver pathologies including necrotic and apoptosis hepatocytes after exposed to 100 and 200 mg/L TiO2-NPs for 20 d. These results
indicated a potential risk from TiO2-NPs released into the aqueous environment. |
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Keywords: | TiO2 nanoparticles carp sub-acute toxicity oxidative stress histopathology |
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