Insect oostatic peptide: absence of effect on mice ovaries

An analogue of insect oostatic peptide, the pentapeptide H-Tyr-Asp-Pro-Ala-Pro-OH (H-YDPAP-OH), was administered to female mice and its effects on reproduction and development of the ovaries were studied. Up to 0.5 mg of the peptide per mice (25 g b.w.) injected intraperitoneally did not change the rate of pregnancy, number of offsprings and histological findings in ovaries and uterus in comparison to saline treated controls.