These authors have equally contributed to this work.;2. Institutes of Biomedical Science, Fudan University, Shanghai 200032, China;3. Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200040, China;4. Key Laboratory of Molecular Medicine, Ministry of Education, Shanghai Medical College, Fudan University, Shanghai 200032, China