Polychlorinated dibenzo-p-dioxins and dibenzofurans in human adipose tissues of Japan |
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Authors: | Mitsuhiro Ono Tadaaki Wakimoto Ryo Tatsukawa Yoshito Masuda |
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Affiliation: | * Department of Environment Conservation, Ehime university, Tarumi 3-5-7, Matsuyama 790, Japan ** Daiichi College of Pharmaceutical Sciences, Minami-Ku, Fukuoka 815, Japan |
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Abstract: | Thirteen samples of human adipose tissue from cancer patients in Japan were analyzed for tetra- to octa- chlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs). These compounds were identified in all the samples analyzed. All isomers identified have a pattern of chlorine substitution in 2, 3, 7 and 8 positions with the only exception of 1,2,3,4,6,7,9-hepta-CDD. In the case of PCDFs, the relatively higher persistency was found in the isomers with chlorine atoms at 4- (or 6-) position as compared with 1- (or 9-) position. Total PCDD concentrations were in the range of 160 to 1400 pg/g on wet weight basis, in which increasing levels were found from tetra- to octa-CDD. Total PCDF concentrations were in the range of 7 to 120 pg/g and the levels of individual congeners are rather uniform. |
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