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| 环境砷中毒人群皮肤损害与DNA氧化损伤的关联性 | |
| 引用本文： | 毛广运,杨佐鹏,任春生,叶晓蕾,王怡,郭小娟.环境砷中毒人群皮肤损害与DNA氧化损伤的关联性[J].中国环境科学,2010,30(1):99-103. |
| 作者姓名： | 毛广运 杨佐鹏 任春生 叶晓蕾 王怡 郭小娟 |
| 作者单位： | 1. 温州医学院环境与公共卫生学院,浙江温州,325035 2. 内蒙古五原县疾病预防控制中心,内蒙古五原,015100 3. 温州医学院环境与公共卫生学院,浙江温州325035;日本产业医科大学环境流行病学研究室,日本,北九州8078555 |
| 基金项目： | 温州市2007年度留学人员科技资助项目，温州市科技计划项目 |
| 摘 要： | 选择内蒙古自治区某县长期暴露于高砷饮用水的人群中有皮肤损害者199人(病例组)和无皮肤损害者91人(对照组)作为研究对象,检测饮用水砷、尿砷和DNA氧化损伤的主要标志物8-羟基脱氧鸟苷(8-OHdG)水平,以分析慢性砷中毒人群DNA氧化损伤与皮肤损害的相关性.结果表明,砷性皮肤损害组和无皮肤损害组人群尿中8-OHdG水平的中位数(四分位间距)分别为4.9(3.5~6.3)μg/g和5.3(4.1~7.2)μg/g,2组对象尿中8-OHdG水平间差异无统计学意义(P=0.074);多元Logistic回归分析结果显示,在校正了年龄、体质指数(BMI)、吸烟、饮酒和饮用高砷水时间等可能的混杂因素后,皮肤损害组人群尿中8-OHdG水平升高的比值比(OR)为1.1(95%CI:0.6,1.9),提示在砷暴露人群中,有无皮肤损害与8-OHdG水平的差异无统计学意义(P=0.863).慢性砷中毒人群皮肤损害与体内的DNA氧化损伤之间无显著的关联性,无皮肤损害人群同样有DNA氧化损伤的风险. |
| 关 键 词： | 慢性砷中毒 皮肤损害 8-OHdG DNA氧化损伤 |
| 收稿时间： | 2009-05-22; |
Association between skin lesions and 8-OHdG among a chronic arsenic exposure population |
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| MAO Guang-yun,YANG Zuo-peng,REN Chun-sheng,YE Xiao-lei,WANG Yi,GUO Xiao-juan.Association between skin lesions and 8-OHdG among a chronic arsenic exposure population[J].China Environmental Science,2010,30(1):99-103. | |
| Authors: | MAO Guang-yun YANG Zuo-peng REN Chun-sheng YE Xiao-lei WANG Yi GUO Xiao-juan |
| Institution: | MAO Guang-yun1,YANG Zuo-peng2,REN Chun-sheng2,YE Xiao-lei1,WANG Yi1,GUO Xiao-juan1,3(1.School of Environmental Science , Public Health,Wenzhou Medical College,Wenzhou 325035,China,2.Center for Disease Control , Prevention in Wuyuan County,Wuyuan 015100,3.Department of Environmental Epidemiology,Institute of Industrial Ecological Science,University of Occupational , Environmental Health,Kitakyushu 8078555,Japan). |
| Abstract: | The association between skin lesions and DNA oxidative damage among a chronic arsenic exposure population was studied by investigating 199 cases with skin lesions and 91 without skin lesions(control group).Concentrations of inorganic arsenic(iAs) in urinary,monomethylarsonic acid(MMA),dimethylarsinic acid(DMA),and 8-hydroxydeoxyguanine(8-OHdG) were measured.Multiple logistic regression was performed to discover the association between skin lesions and DNA oxidative damage.Among participants with skin lesion... |
| Keywords: | 8-OHdG arsenic exposure skin lesion 8-OHdG DNA oxidative damage |
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