| 环境中抗药基因水平转移研究进展 |
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| 引用本文： | 刘苗苗,杨敏,张昱,姚宏.环境中抗药基因水平转移研究进展[J].生态毒理学报,2015,10(5):11-19. |
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| 作者姓名： | 刘苗苗 杨敏 张昱 姚宏 |
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| 作者单位： | 1. 北京交通大学土木建筑工程学院市政环境工程系水中典型污染物控制与水质保障北京市重点实验室,北京,100044;2. 中国科学院生态环境研究中心环境水质学国家重点实验室,北京,100085 |
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| 基金项目： | 国家自然科学基金青年基金(51408032)；环境模拟与污染控制国家重点联合实验室(中国科学院生态环境研究中心)专项经费(14K01ESPCR)。 |
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| 摘 要： | 抗药基因是一种新型环境污染物,一旦被致病菌获得,将导致抗生素的临床使用失效,从而危害公共健康。抗药基因可通过转移因子在细菌间传播,加剧抗药基因的扩散效应,提升了环境健康风险性,因此抗药基因水平转移受到了越来越多的关注。本文介绍了抗药基因水平转移的分子机制,总结了不同环境中各种抗药基因水平转移途径的研究现状,并对该领域将来的研究方向提出了展望,以期为环境中抗药基因的调查评估、污染控制及合理管理提供理论参考。
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| 关 键 词： | 抗药基因 水平转移 质粒 整合子 噬菌体 |
| 收稿时间： | 6/1/2015 12:00:00 AM |
| 修稿时间： | 2015/8/24 0:00:00 |
Horizontal Transfer of Antibiotic Resistance Genes in Environment: A Review |
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| Liu Miaomiao,Yang Min,Zhang Yu,Yao Hong,Liu Miaomiao,Yang Min,Zhang Yu,Yao Hong,Liu Miaomiao,Yang Min,Zhang Yu,Yao Hong and Liu Miaomiao,Yang Min,Zhang Yu,Yao Hong.Horizontal Transfer of Antibiotic Resistance Genes in Environment: A Review[J].Asian Journal of Ecotoxicology,2015,10(5):11-19. |
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| Authors: | Liu Miaomiao Yang Min Zhang Yu Yao Hong Liu Miaomiao Yang Min Zhang Yu Yao Hong Liu Miaomiao Yang Min Zhang Yu Yao Hong and Liu Miaomiao Yang Min Zhang Yu Yao Hong |
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| Institution: | 1. Department of Municipal and Environmental Engineering, Beijing Jiaotong University, Beijing 100044, China
2. State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China;1. Department of Municipal and Environmental Engineering, Beijing Jiaotong University, Beijing 100044, China
2. State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China;1. Department of Municipal and Environmental Engineering, Beijing Jiaotong University, Beijing 100044, China
2. State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China;1. Department of Municipal and Environmental Engineering, Beijing Jiaotong University, Beijing 100044, China
2. State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China |
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| Abstract: | Antibiotic resistance genes are a major emerging environmental pollutant of concern as they reduce the efficacy of antibiotic medical treatment and consequently threaten public health. Horizontal gene transfer of such genes between bacteria greatly accelerates the spread of antibiotic resistance, intensifying the public health risk. Thus, the mobility of antibiotic resistance genes has drawn increasing attention worldwide. This review introduces the molecular mechanisms of the horizontal transfer of antibiotic resistance genes. It is summarized that the variation of these mechanisms amongst different environments. Based on this current progress, future research directions are proposed. Overall, this review aims to provide insight for the future survey and control of antibiotic resistance genes in the environment. |
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| Keywords: | antibiotic resistance genes horizontal transfer plasmids integrons bacteriophage |
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