Differential global profiling as a new analytical strategy for revealing micropollutant treatment by-products: application to ethinylestradiol and chlorination water treatment |
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Authors: | Gervais Gaël Bichon Emmanuelle Antignac Jean-Philippe Monteau Fabrice Leroy Gaëla Barritaud Lauriane Chachignon Mathilde Ingrand Valérie Roche Pascal Le Bizec Bruno |
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Institution: | a ONIRIS, USC 2013, LABERCA, Nantes F-44307, France b Université Nantes Angers Le Mans, France c INRA, Nantes F-44307, France d Veolia Environnement Recherche et Innovation, Centre de Recherche de Saint Maurice, 1 Place de Turenne, F-94417 Saint-Maurice Cedex, France e Veolia Environnement Recherche et Innovation, Centre de Recherche sur l’Eau Chemin de la Digue, BP 76, F-78603 Maisons-Laffitte Cedex, France |
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Abstract: | The detection and structural elucidation of micropollutants treatment by-products are major issues to estimate efficiencies of the processes employed for drinking water production versus endocrine disruptive compounds contamination. This issue was mainly investigated at the laboratory scale and in high concentration conditions. However, potential by-products generated after chlorination can be influenced by the dilution factor employed in real conditions. The present study proposes a new methodology borrowed to the metabolomic science, using liquid chromatography coupled to high-resolution mass spectrometry, in order to reveal potential chlorination by-products of ethinylestradiol in spiked real water samples at the part-per-billion level (5 μg L−1). Conventional targeted measurements first demonstrated that chlorination with sodium hypochlorite (0.8 mg L−1) led to removals of ethinylestradiol over 97%. Then, the developed differential global profiling approach permitted to reveal eight chlorination by-products of EE2, six of them being described for the first time. Among these eight halogenated compounds, five have been structurally identified, demonstrating the potential capabilities of this new methodology applied to environmental samples. |
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Keywords: | Chlorination Ethinylestradiol LC-HRMS Drinking water By-products determination |
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