Hydractinia echinata test system. II. SAR toxicity study of some anilide derivatives of Naphthol-AS type |
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Authors: | Chicu Sergiu Adrian Funar-Timofei Simona Simu Georgeta-Maria |
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Institution: | a Institute of Chemistry Timi?oara of the Romanian Academy, B-dul Mihai Viteazul 24, RO-300223 Timi?oara, Romania b University of Medicine and Pharmacy Victor Babe? Timi?oara, Faculty of Pharmacy, Piata Eftimie Murgu 2-4, RO-300034 Timi?oara, Romania |
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Abstract: | In this paper, a toxicity study for a series of anilides of Naphthol-AS type is presented. The toxicity of the model compounds was determined by using the Hydractinia echinata (Hydrozoa) test system. Conformational analysis of Naphthol-AS derivatives was performed to elucidate the possible enzymatic hydrolysis mechanism of these compounds. This mechanism occurs with different rates and always leads to a stoichiometric mixture of reaction products, consisting in the substituted amine and the corresponding α-hydroxy-carboxylic acid. With one exception, the toxicities of the reaction products are subadditive. Quite similar measured toxicity values, log(1/MRC50), led to their average calculated values, and thus to the establishment of class isotoxicity. This method represents a practical alternative useful for the reduction of experimental tests on animals to the lowest possible level, in accordance to the ‘3Rs’ (reduction, refinement and replacement) concept. |
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Keywords: | Hydractinia echinata Naphthol-AS Class isotoxicity Omega software Conformational analysis |
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