Comparison of the concentrations of polychlorinated biphenyls and dioxins in mothers affected by the Yusho incident and their children |
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Authors: | Tsukimori Kiyomi Uchi Hiroshi Mitoma Chikage Yasukawa Fumiko Fukushima Kotaro Todaka Takashi Kajiwara Junboku Yoshimura Takesumi Hirata Teruaki Wake Norio Furue Masutaka |
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Institution: | a Department of Obstetrics, Fukuoka Children’s Hospital, Tojinmachi 2-5-1, Chuo-ku, Fukuoka 810-0063, Japan b Research and Clinical Center for Yusho and Dioxin, Kyushu University Hospital, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan c Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan d Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan e Fukuoka Institute of Health and Environmental Science, 39 Mukaizano, Dazaifu-shi, Fukuoka 818-0135, Japan |
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Abstract: | Accumulated maternal dioxins are passed onto the fetus and neonate via the placenta and maternal milk. In Japan in 1968, an accidental human exposure to rice oil contaminated with polychlorinated biphenyls (PCBs) and other dioxin-related compounds, such as polychlorinated dibenzofurans (PCDFs), led to development of Yusho oil disease. We investigated differences in blood dioxin concentrations in mother-children pairs affected by the Yusho incident. From 2002 to 2008, blood samples were collected from 26 pairs of Yusho mothers and their children (19 mothers, 26 children). Specific congeners of seven polychlorinated dibenzo-p-dioxins (PCDDs), ten PCDFs, and four non-ortho PCBs were analyzed. The children had significantly lower TEQ concentrations of PCDDs, PCDFs, and coplanar PCBs compared to their mothers. The mother-child difference in blood concentrations varied with the congeners; the largest for 2,3,4,7,8-pentaCDF and the smallest for 1,2,3,4,6,7,8-heptaCDD. The level for 2,3,4,7,8-pentaCDF, which characterizes Yusho oil disease, was approximately 17-30 times higher in the mothers than in the general population, whereas there were no significant differences between children in the formula-fed group and the general population. In contrast, the mean level for 2,3,4,7,8-pentaCDF in the breast-fed group was approximately 1.5 times, (range 0.5-6.5 times) higher than that in the general population. Over 30 years after the Yusho incident, the mean blood dioxin levels in the offspring were only a fraction of the levels in their mothers. This is more consistent with exposure via breast milk than via transplacental transfer in the Yusho incident. |
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Keywords: | Yusho Dioxin Polychlorinated biphenyls (PCBs) Children&rsquo s blood levels Body burdens Maternal blood |
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