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Associations between maternal phthalate exposure and cord sex hormones in human infants |
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| Authors: | Lin Lung-Cheng Wang Shu-Li Chang Yu-Chen Huang Po-Chin Cheng Joan-Tin Su Pen-Hua Liao Pao-Chi |
| Institution: | a Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan b Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Miaoli 350, Taiwan c Institute of Environmental Medicine, College of Public Health, China Medical University and Hospital, Taichung, Taiwan d Department of Pediatrics, Division of Genetics, Chung Shan Medical University Hospital, Taichung 402, Taiwan e School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan f Sustainable Environment Research Center, National Cheng Kung University, University Road, Tainan 701, Taiwan |
| Abstract: | It has been speculated that maternal phthalate exposure may affect reproductive development in human newborns. However, the mechanism awaits further investigation. The aim is to evaluate the association between maternal phthalate exposure and cord sex steroid hormones in pregnant women and their newborns from the general population. A total of 155 maternal and infant pair were recruited and analyzed. Levels of urinary phthalate metabolites and sex steroid hormones were determined using liquid chromatography/electrospray tandem mass spectrometry (LC-ESI-MS/MS) and radioimmunoassay (RIA), respectively. No significant correlation was found between each steroid hormones and phthalate metabolites for male newborns, except MMP was marginally significantly correlated with E2. After adjusting for maternal age, estradiol (E2) levels in cord serum from male newborns were not correlated with maternal urinary phthalate metabolites. In female newborns, the maternal urinary levels of mono-(2-ethylhexyl) phthalate (MEHP) and mono-(2-ethyl-5-hydroxyhexyl) phthalate (5OH-MEHP) were negatively correlated with the free testosterone (fT) and fT/E2 levels in cord serum with Pearson correlation coefficients ranging between −0.24 and −0.29 (p < 0.05). Additionally, after gestational age was adjusted, the maternal urinary level of DEHP was negatively correlated with the free testosterone (fT) and fT/E2 levels in cord serum. We suggest that maternal exposure to phthalates may affect sex steroid hormones status in fetal and newborn stage. |
| Keywords: | Sex steroid hormones Maternal exposure Phthalate Umbilical cord blood |
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