| Abstract: | The sperm-shape abnormality bioassay in mice was used to determine whether chemical mutagens in diesel exhaust reach the testes. Strain A male mice (30 per group from 4 to 6 weeks of age) were exposed for 31 or 39 weeks to either diesel exhaust or clean air. After exposure, Eosin Y-stained, air-dried smears of cauda epididymal sperm were scored for changes in sperm-head abnormalities in three different laboratories. There was no difference in the proportion of abnormally shaped sperm in controls and mice exposed to diesel exhaust. |
