基于生态风险的我国水环境高风险抗生素筛选排序

针对我国水体环境中大多数抗生素缺乏生态毒理数据,无法开展全国范围内抗生素生态风险评估的问题,以国家药品监督管理局数据库中抗生素商品为研究对象,通过收集市场所有抗生素的商品数量和平均日剂量,结合暴露建模方法计算暴露指数,采用抗生素生态毒理效应数据以及物种敏感性分布(species sensitivity distribu...

Screening and Sequencing High-risk Antibiotics in China's Water Environment Based on Ecological Risks

In view of the lack of ecotoxicological data for most antibiotics in China''s water environment, national-scale ecological risk assessment of antibiotics remains impossible. This study determined the exposure index values for antibiotic products in the National Medical Products Administration based on quantity and average daily dose data for all antibiotics in the market alongside exposure modeling. The risk scores were calculated using data on the ecotoxicological effects of the antibiotics, and the species sensitivity distributions (SSD) method and apical effects. Priorities for control were identified based on the findings. Approximately 105 antibiotics were screened, and 53 were identified as candidate drugs with high national usage. Twenty antibiotics were identified for priority risk evaluation using a joint probabilistic model, with clarithromycin, ciprofloxacin, amoxicillin, cefaclor, and oxyfloxacin highlighted as presenting a high ecological risk. This study provides a scientific basis for the quantitative assessment of antibiotic risk prevention and control in China''s aquatic environment.