基于表面增强拉曼光谱技术的饮用水中痕量恩诺沙星和环丙沙星快速检测

近年来，抗生素的滥用引发抗生素抗性基因在环境中的传播和扩散，对生态系统与人类健康构成潜在威胁，特别是饮用水中抗生素污染事件的相关报道引发社会极大关注.因此，如何实现应急公共卫生事件中的痕量抗生素快检成为研究热点.基于表面增强拉曼光谱（SERS）技术，并结合磁性固相萃取（MSPE）样品前处理方法，构建了饮用水水样中ng ·L^-1水平喹诺酮类抗生素的快速检测方法.借助于磁性氧化石墨烯复合纳米材料（Fe₃ O₄@SiO₂-GO）的高吸附容量所提供的高富集能力，成功实现了饮用水中1.0 ng ·L^-1恩诺沙星（ENR）和5.0 ng ·L^-1环丙沙星（CIP）的加标检出，回收率在77.5%~91.5%之间，满足当前饮用水水质检测的要求.对于有机基质复杂的湖水等环境水样，萃取材料的选择性尚有待于进一步提升.

Rapid Detection of Trace Enrofloxacin and Ciprofloxacin in Drinking Water by SERS

In recent years, the abuse of antibiotics has led to the spread and diffusion of antibiotic resistance genes in the environment, which poses a potential threat to the ecosystem and human health. In particular, the related reports of antibiotic contamination in drinking water have aroused great social concerns. Therefore, realizing the rapid detection of trace antibiotics in emergency events has become a research hotspot. Here, in combination with magnetic solid phase extraction (MSPE), we established a rapid detection strategy for ng·L^-1 level quinolones in drinking water using surface-enhanced Raman spectroscopy (SERS). With the help of the high enrichment capacity provided by the high adsorption capacity of the magnetic graphene oxide composite nanomaterial (Fe₃O₄@SiO₂-GO), the spiked detection of 1.0 ng·L^-1 enrofloxacin (ENR) and 5.0 ng·L^-1 ciprofloxacin (CIP) in drinking water was successfully achieved, with recoveries ranging from 77.5% to 91.5%, which met the current requirements of drinking water testing. For environmental water samples such as lake water, the selectivity of extraction materials needs to be further improved due to the strong interference of the complex organic matrix.