II. Enhancement of gas transport in inositol hexaphosphate-loaded red blood cells |
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Authors: | Klaus Gersonde Claude Nicolau |
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Affiliation: | 1. Abteilung für Physiologische Chemie der Technischen Hochschule, D-5100, Aachen 2. Institut für Strahlenchemie im Max-Planck-Institut für Kohlenforschung, D-4330, Mülheim (Ruhr)
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Abstract: | The gas-transport function of red blood cells which have incorporated inositol hexaphosphate is significantly improved by fusion with effector-loaded lipid vesicles. “Right-shifts” of the O2-binding curves of inositol hexaphosphate-loaded red blood cells with half-saturation pressures at 37 °C up to 98 mmHg are observed. The transformation of 56% of the intracellular haemoglobin into the low affinity state corresponds to an optimum increase of the O2-release capacity of 270%. The CO2 transport is also correspondingly enhanced. The treated red blood cells show no inositol hexaphosphate depletion during a reasonable time. |
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