Ochratoxin A and Penicillic acid interaction in mice |
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Authors: | Eric C Shepherd Timothy D Phillips Gary N Joiner Leon F Kubena Norman D Heidelbaugh |
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Institution: | 1. Department of Veterinary Public Health , Texas A&2. M University , College Station, Texas, 77843;3. USDA, SEA/AR , VTERL , College Station, Texas |
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Abstract: | Abstract Penicillic Acid (PA) and Ochratoxin A (OA) are toxic fungal metabolites that are synergistic in combination. This interaction was investigated using mice which were dosed orally as follows: control, none; solvent control, 0.2 ml bicarbonate buffer; PA, 40 mg/kg; OA, 10 mg/kg and combination, 40 mg/kg PA + 10 mg/kg OA. The only significant histopathologic change observed was an acute multifocal toxic tubular nephrosis which appeared most severe in the combination‐treated mice killed on day 10. While the combination group had a death rate of 20% (5/25), no deaths occurred in the other treatment groups. The increased death rate and the extensive nephrotoxic findings in the combination group indicate a toxic interaction between OA and PA at sub‐lethal dose levels and is consistent with a renal site of action. |
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Keywords: | Ochratoxin A Penicillic Acid Mycotoxins |
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