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In vitro study of oxytetracycline adsorption on activated charcoal |
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| Authors: | A K Alegakis M N Tzatzarakis A M Tsatsakis I G Vlachonikolis V Liakou |
| Institution: | 1. Laboratory of Toxicology, Medical School , University of Crete , Voutes, Heraklio, Crete, 71409, Greece;2. Laboratory of Toxicology, Medical School , University of Crete , Voutes, Heraklio, Crete, 71409, Greece E-mail: aris@med.uoc.gr;3. Biostatistics Unit, Medical School , University of Crete Voutes , Heraklio, Crete, 71409, Greece;4. Laboratory of Microbiology , Venizelion Hospital , Agios Ioannis, Heraklio, Crete, 71110, Greece |
| Abstract: | Abstract In vitro adsorption experiments simulating pH in gastric environment and using Langmuir isotherm, showed that 408 mg of oxytetracycline was adsorbed per gram of activated charcoal. Langmuir isotherm fitted adsorption data better than a Freundlich isotherm. Freundlich isotherm showed a specific adsorption capacity of 518 mg/g for activated charcoal. Both isotherm parameters indicated a strong oxytetracycline adsorption on activated charcoal in terms of quantity and binding strength. The results demonstrate that the concomitant use of oxytetracyline and activated charcoal should be avoided. |
| Keywords: | In vitro oxytetracycline activated charcoal adsorption capacity |