Effects of repeated fumonisin B1 exposure on markers of oxidative stress in liver,kidneys, and lungs of C57BL/6 mice

Abstract

Fu monisin B₁ (FB₁) is a mycotoxin commonly found in maize and maize-based products. Ingestion of FB₁-contaminated causes a myriad of dose- and species-dependent toxic effects to human and animal health. In the present study we evaluated the effects of FB₁ (8?mg/kg, i.p. for 4?days) on body weight and oxidative stress parameters in the liver, kidney and lung of C57BL/6 male mice. No changes in the organ-to-body weight ratio, organ-to-adrenal gland weight ratio or organ-to-brain weight ratio were found. On the other hand, FB₁ exposure increased NPSH levels in liver and lungs whereas decreased FRAP content in liver and kidneys. Levels of TBARS, ascorbic acid and NOx content were not altered by FB₁. In summary, four days of FB₁ exposure are sufficient to disrupt antioxidant defenses in liver, kidneys and lungs of C57BL/6 male mice without concomitant changes in organs weight.