Effect and mechanism of action of methomyl and cypermethrin insecticides on kynurenine metabolizing enzymes of mouse liver |
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| Authors: | SM El‐Scwedy M A Zahran MA Zeidan MH Mostafa EA El‐Bassiouni |
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| Institution: | Departments of Applied Medical Chemistry and Pharmacology, Medical Research Institute, and Department of Biochemistry, Faculty of Medicine , Alexandria University , Egypt |
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| Abstract: | Abstract The effect of methomyl and cypermethrin insecticides on the B6‐dependent kynurenine hydrolase(KH) and kynurenine aminotransferase (KATE) was studied. These insecticides induced pronounced inhibition on the (KH) and (KATE) enzymes after single dose treatment. Repeated doses of methomyl induced inhibition on the (KH) and (KATE) activities, whereas repeated treatment with cypermethrin had no effect on the activities of these enzymes. In vitro methomyl inhibited (KH) and (KATE) enzymes at 10 M up to 10‐3 M, through a competitive mechanism. Methomyl and cypermethrin are capable of causing alterations in the kynurenine metabolizing enzymes of mouse liver. |
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| Keywords: | Methomyl Cypermethrin Insecticides Kynurenine Hydrolase Kynurenine Aminotransferase Mouse liver |
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